Pathogeny of wool cell leukaemia, leukaemia of cell of the reason childhood of wool cell leukaemia chronic bead

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Pathogeny of wool cell leukaemia, pathogeny of leukaemia of cell of the reason childhood of wool cell leukaemia chronic bead, pathogeny of leukaemia of cell of the reason childhood of leukaemia of cell of childhood chronic bead chronic bead, the introduction of net of reason the way to keep in good health of leukaemia of cell of childhood chronic bead: The article introduces the pathology pathogeny of leukaemia of cell of childhood chronic bead in detail to you, childhood chronic bead cellular leukaemia

Introduction of net of the way to keep in good health: The article introduces the pathology pathogeny of leukaemia of cell of childhood chronic bead in detail to you, leukaemia of cell of childhood chronic bead basically is caused by what reason.

One, pathogeny of leukaemia of cell of childhood chronic bead

One, Fall in love with sea otter phoenix 419 sauna

Sh1f of Shanghai Long Feng forum
Hair cause of disease because

Ph1 is the change of mark sex chromosome of CML, by be not random T(9;22)(q34;q11) to form. Rupture in 9 chromosome there is C-abl gene on the dot, its variability can be more than 100kb. Bcr gene is located in 22 chromosome, it is the 5.8kb DNA small part with a very small variability, easy hind 22q- and 9q union department form Bcr/abl shirt-sleeve gene, encode a distinctive 210kb is protein (P210) , it is acerbity kinase of ammonia of a kind of cheese, in tumor in coming on, act well. Ph1 chromosome still has its special case in children CML.

1.Ph1 is electronegative 10% have CML 5% ~ typical CML, the Ph1 of case of illness of clinical expression is electronegative, the likelihood has the following reason:

(Extract of 1) other chromosome is united in wedlock at 22q, make the 22q- of Ph1 detects not easily in cellular genetics level.

(2)9 date chromosome has rupture or gene recomposition, but 22q11 did not rupture, molecular biology technology can detect these change when giving CML Ph1 negative.

Chromosome of Ph1 of leukaemia of 2.Ph1 electropositive acute not in consist in CML, the children acute leukaemia of 10% has 3% ~ Ph1 chromosome. Leukaemia of Ph1 electropositive acute can be CML leap, also may be the acute leukaemia of former hair. Be in clinical it is very difficult that in be being checked with hematology, these two kinds of cases are distinguished, but the blame random chromosome that examination of technology of biology of member of cellular genetics union can discover CML of Chang Weifei of leukaemia of Ph1 electropositive acute is distinctive is unusual T(9;22)(q34;q11) , have the gene recomposition beyond Bcr gene, produce 190kb protein (P190) , the Ph1 chromosome in medullary after cure alleviates cell and P190 can disappear. And CML is contrary, CML is not random chromosome distinctively unusual T(9;22)(q34;q11) , no matter be in which period of the disease, ph1 chromosome and the 210kb protein that place of Bcr gene recomposition produces (P210) exists from beginning to end.

2, send ill mechanism

CML hair interpretation of the cause is made up to now unidentified, think this disease is commonly much can disease of hematopoiesis dry cell, its happen to have particular concern with certain and chemical material and genetic element. Nowell and Hungerford discovered in Philadelphia CML patient has Ph chromosome first 1960. At present most scholar thinks, ph chromosome has special sense to the diagnosis of CML, positive rate is 70% ~ 90% . Because date and the 22nd the 9th chromosome are easy,Rowley fixed Ph chromosome 1973 is form, namely T(9: 22)(q34: Q11) . Current and foregone this kind of chromosome is easy, the Bcr cancer gene on the C-ab1 of former cancer gene that makes be located in 9q34 to go up normally and 22q11 is shirt-sleeve, expression has kinase of acerbity albumen of tall cheese ammonia (the BCR-ABL shirt-sleeve albumen of PTK) active, this albumen is considered as the molecular foundation that CML comes on. Nearly two years abroad is opposite on molecular level the diversity of albumen of confluence of the hair ill mechanism of CML, BCR-ABL and its and leukaemia watch the relation made more thorough research, already discovered way of recomposition of gene of confluence of 3 kinds of BCR-ABL at present. Because ABL gene ruptures,the exact position of the dot is changeful, can appear in this gene 5 ‘ upright > any section of 300kb, and of BCR gene rupture area of dot crowd together basically has 3, so BCR-ABL shirt-sleeve gene ruptures according to BCR gene spot position cent is 3 main types: M-bcr, M-bcr, μ – Bcr and 6 kinds of BCR-ABL, shirt-sleeve transcribe means: B2a2, B3a2, B3a3, B2a3, E1a2, E19a2.

1.M-bcr BCR gene ruptures the dot is in of 5.8kb basically rupture bit of crowd together area, show outside the 12-165 of this gene namely child inside the area, have B2a2, B3a2, B3a3, B2a3 with the shirt-sleeve transcribe means of ABL gene, encode albumen is P210. This model see at great majority CML is mixed leukaemia of partial acute lymphocyte (ALL) . Bead of P210 CML main drag in is, suffocate suffocate of major cell maturity at phase of medium, Wan Youli, pair of red departments, odd nucleus department and lymphatic department influence are minor.

2.m-bcrBCR ruptures the dot is located in farther upriver area, outer show child what 54.4kb grows between E1 and E2 is embedded child in, call less important Bcr, with ABL confluence transcribe means is Ela2, p190 of encode confluence albumen. This model see at few number CML is mixed major ALL. P190 but at the same time drag in bead, one-celled department, expression is mix absolutely opposite monocyte grow in quantity, mature and neuter bead, one-celled than low, the be addicted to that has different rate is alkalescent bead cell grow in quantity, outside scale of cell of bead of Zhou Xieyou childish is relative taller, neuter bead cell is alkalescent phosphoric acid enzymatic integral is low.

3. μ – Bcr BCR ruptures bit outside be located in, show child between E19 and E20, call 3 ‘ upright BCR ruptures dot, with ABL confluence means is E19a2, p230 of encode confluence albumen, see at seldom counting slow bead leap is mixed leukaemia of cell of chronic and neuter bead (CNL) . This model main feature is hyperplasia of cell of mature and neuter bead to give priority to, expression is ” hide or benign ” clinical course, live period longer. Ph cell is likely the unusual change because of BCR-ABL shirt-sleeve albumen, the ability of composition of the matrix outside cell of adhere marrow matrix and other cell drops, make crudely the cell releases blood from marrow, make thereby crudely the cell escaped medullary matrix small environment the normal adjusting control of proliferous to its, become divided.

Research still discovers to there is negative of chromosome of 5% ~ 10%Ph in CML patient. Patient of Ph chromosome negative although cellular genetics did not discover T(9;22) , but molecular level research, ph chromosome is electronegative (Ph-CML) can be divided again recombine to have Bcr (Ph-bcr CML) and recombine without Bcr (Ph-bcr- CML) two inferior model. Most Ph? CML patient is Ph-bcr CML, ph-bcr-CML patient is minority only. A few authors think latter is likely is slow bead odd leukaemia (CMML) . The branch of research of molecular biology technology to Ph-CML have important sense, have fair value to the patient’s diagnosis, cure and estimation prognosis. Think now Ph? Bcr CML and Ph CML have show of same clinical, hematology, produce acute to change with same way, to α – interferon (the remedial effect of IFN-a) is better; and Ph-bcr-CML patient its are clinical behave with hematology all not typical, poorer also to the curative effect of IFN-a. Normally cent is CML 3 period, namely chronic period, quickly period and evil change period, latter is main cause of death. The remedial method with effective only is medullary transplanting (BMT) , especially chronic period curative effect is apparent excel is terminal. Accordingly, choose the most appropriate BMT time to be the key that the patient survives for a long time. But, still forecast its without reliable method up to now evil the time that change. In recent years foreign somebody reported other people of a kind of new molecular gene mark, namely the 11st chromosome short arm (11P) falls calcic element (CT) gene is unusually methylic change a change to be able to monitor CML aggravation. Research hair is chronic now period, it is more normal and methylic change, but can transform into exhibition period in the disease Cheng Chaojia base change. This kind exceeds methylic the Hpa Ⅱ segment that change (3.1Kb) is in clew CML will happen on average inside 6 months evil change (morphology is reached in clinical expression evil before changing) . Accordingly, CT gene height is methylic change can indicate as gene of element of evolutional of the clinical disease that monitor. Pass methylic to CT gene change position even爱上海 is the same as edition of city mobile phone

New love Shanghai is opposite with the city touch forum
Add analysis, can choose patient and buy time to provide a basis for clinical BMT.

Warmth of net of the way to keep in good health hints: Above is to pathogeny of leukaemia of cell of childhood chronic bead, leukaemia of cell of childhood chronic bead is by what reason the relevant content that cause is narrated, more concerns the knowledge of respect of leukaemia of cell of childhood chronic bead, continue to pay close attention to library of disease of net of the way to keep in good health please, perhaps search inside the station ” leukaemia of cell of childhood chronic bead ” find more and patulous content, hope above content can help you!

Introduction of net of the way to keep in good health: The article introduces the pathology pathogeny of wool cell leukaemia in detail to you, wool cell leukaemia basically is caused by what reason.

One, pathogeny of wool cell leukaemia

One, hair cause of disease because:

The pathogeny of 1.HCL not bright, ceng Di gives Ⅱ of virus of leukaemia of person T cell (HTLV- Ⅱ ) , EB virus infection and HCL are concerned. The healthy crowd of correspondence of photograph of ace of incidence of a disease of the person that contact ray or organic dissolvent. Afore-mentioned pathogenies all have a controversy quite, did not obtain approbate. Because have familial in many report that produces HCL, at the same time partial HCL patient has distortion of sex of 12 chromosome clone, 14q respectively, 5, the chromosome such as Del(5q13) is unusual, reason thinks genetic element may come on with HCL about, but did not win consensus likewise.

2, send ill mechanism:

1.HC is put in recomposition of gene of clone sex IgH, but never check gives TCR gene recomposition, reason already was B lymphocyte origin certainly. HC conveys antigen of become divided of B cell surface, if CD19, CD20, CD22 reachs SIg, and do not convey CD10 of mark of inchoate B cell, clew HC is the one B cell that mature level spends in planting. The author puts forward cell of B of area of lymph node brim is the genetic cell of HC, the babyish B lymphocyte in be equivalent to normal circulation reachs lymphocyte of B of odd nucleus appearance. Discover HC still conveys PCA-1 of mark of inchoate oar cell at the same time, indicate level of cell of the oar before its are in. HC surface but check gives a variety of Ig to weigh catenary, support cell of brim area B to may be the normal and corresponding cell of malign HC more.

What 2. cancer gene knows in the action in coming on is very little. Already discovered the M-CSF that C-fms codes suffers爱上海 is opposite with the city touch

爱上海 is the same as city forum
Body shows tall expression in HC, the stimulation that can pass M-CSF thereby promotes the hyperplasia of HC. Additional discovery the Pp60 of child of C-src of former cancer gene of HCL, namely the level of acerbity kinase of ammonia of a kind of cheese and active heighten, cause the proliferation of HC.

Warmth of net of the way to keep in good health hints: Above is fine to wool afterbirth leukaemia pathogeny, wool cell leukaemia is the relevant content that causes by what reason is narrated, more concerns the knowledge of respect of wool cell leukaemia, continue to pay close attention to library of disease of net of the way to keep in good health please, perhaps search inside the station ” wool cell leukaemia ” find more and patulous content, hope above content can help you!


Pathogeny of wool cell leukaemia, the reason childhood of wool cell leukaemia chronic bead cellular leukaemia

On May 28, 2016 23:00 editors: Net of legend preserve one’s health


Introduction of net of the way to keep in good health: The article introduces the pathology pathogeny of leukaemia of cell of childhood chronic bead in detail to you, leukaemia of cell of childhood chronic bead basically is caused by what reason.

One, pathogeny of leukaemia of cell of childhood chronic bead

One, hair cause of disease because

Ph1 is the change of mark sex chromosome of CML, by be not random T(9;22)(q34;q11) to form. Rupture in 9 chromosome there is C-abl gene on the dot, its variability can be more than 100kb. Bcr gene is located in 22Shanghai night net

A falls in love with the sea to be the same as a city
Chromosome, it is the 5.8kb DNA small part with a very small variability, easy hind 22q- and 9q union department form Bcr/abl shirt-sleeve gene, encode a distinctive 210kb is protein (P210) , it is a kind of cheese1000 beautiful nets of Shanghai

爱上海 is opposite with the city touch
Ammoniac acerbity kinase, in tumor in coming on, act well. Ph1 chromosome still has its special case in children CML.

1.Ph1 is electronegative 10% have CML 5% ~ typical CML, the Ph1 of case of illness of clinical expression is electronegative, the likelihood has the following reason:

(Extract of 1) other chromosome is united in wedlock at 22q, make the 22q- of Ph1 detects not easily in cellular genetics level.

(2)9 date chromosome has rupture or gene recomposition, but 22q11 did not rupture, molecular biology technology can detect these change when giving CML Ph1 negative.

Chromosome of Ph1 of leukaemia of 2.Ph1 electropositive acute not in consist in CML, the children acute leukaemia of 10% has 3% ~ Ph1 chromosome. Leukaemia of Ph1 electropositive acute can be CML leap, also may be the acute leukaemia of former hair. Be in clinical it is very difficult that in be being checked with hematology, these two kinds of cases are distinguished, but the blame random chromosome that examination of technology of biology of member of cellular genetics union can discover CML of Chang Weifei of leukaemia of Ph1 electropositive acute is distinctive is unusual T(9;22)(q34;q11) , have the gene recomposition beyond Bcr gene, produce 190kb protein (P190) , the Ph1 chromosome in medullary after cure alleviates cell and P190 can disappear. And CML is contrary, CML is not random chromosome distinctively unusual T(9;22)(q34;q11) , no matter be in which period of the disease, ph1 chromosome and the 210kb protein that place of Bcr gene recomposition produces (P210) exists from beginning to end.

2, send ill mechanism

CML hair interpretation of the cause is made up to now unidentified, think this disease is commonly much can disease of hematopoiesis dry cell, its happen to have particular concern with certain and chemical material and genetic element. Nowell and Hungerford discovered in Philadelphia CML patient has Ph chromosome first 1960. At present most scholar thinks, ph chromosome has special sense to the diagnosis of CML, positive rate is 70% ~ 90% . Because date and the 22nd the 9th chromosome are easy,Rowley fixed Ph chromosome 1973 is form, namely T(9: 22)(q34: Q11) . Current and foregone this kind of chromosome is easy, the Bcr cancer gene on the C-ab1 of former cancer gene that makes be located in 9q34 to go up normally and 22q11 is shirt-sleeve, expression has kinase of acerbity albumen of tall cheese ammonia (the BCR-ABL shirt-sleeve albumen of PTK) active, this albumen is considered as the molecular foundation that CML comes on. Nearly two years abroad is opposite on molecular level the diversity of albumen of confluence of the hair ill mechanism of CML, BCR-ABL and its and leukaemia watch the relation made more thorough research, already discovered way of recomposition of gene of confluence of 3 kinds of BCR-ABL at present. Because ABL gene ruptures,the exact position of the dot is changeful, can appear in this gene 5 ‘ upright > any section of 300kb, and of BCR gene rupture area of dot crowd together basically has 3, so BCR-ABL shirt-sleeve gene ruptures according to BCR gene spot position cent is 3 main types: M-bcr, M-bcr, μ – Bcr and 6 kinds of BCR-ABL, shirt-sleeve transcribe means: B2a2, B3a2, B3a3, B2a3, E1a2, E19a2.

1.M-bcr BCR gene ruptures the dot is in of 5.8kb basically rupture bit of crowd together area, show outside the 12-165 of this gene namely child inside the area, have B2a2, B3a2, B3a3, B2a3 with the shirt-sleeve transcribe means of ABL gene, encode albumen is P210. This model see at great majority CML is mixed leukaemia of partial acute lymphocyte (ALL) . Bead of P210 CML main drag in is, suffocate suffocate of major cell maturity at phase of medium, Wan Youli, pair of red departments, odd nucleus department and lymphatic department influence are minor.

2.m-bcrBCR ruptures the dot is located in farther upriver area, outer show child what 54.4kb grows between E1 and E2 is embedded child in, call less important Bcr, with ABL confluence transcribe means is Ela2, p190 of encode confluence albumen. This model see at few number CML is mixed major ALL. P190 but at the same time drag in bead, one-celled department, expression is mix absolutely opposite monocyte grow in quantity, mature and neuter bead, one-celled than low, the be addicted to that has different rate is alkalescent bead cell grow in quantity, outside scale of cell of bead of Zhou Xieyou childish is relative taller, neuter bead cell is alkalescent phosphoric acid enzymatic integral is low.

3. μ – Bcr BCR ruptures bit outside be located in, show child between E19 and E20, call 3 ‘ upright BCR ruptures dot, with ABL confluence means is E19a2, p230 of encode confluence albumen, see at seldom counting slow bead leap is mixed leukaemia of cell of chronic and neuter bead (CNL) . This model main feature is hyperplasia of cell of mature and neuter bead to give priority to, expression is ” hide or benign ” clinical course, live period longer. Ph cell is likely the unusual change because of BCR-ABL shirt-sleeve albumen, the ability of composition of the matrix outside cell of adhere marrow matrix and other cell drops, make crudely the cell releases blood from marrow, make thereby crudely the cell escaped medullary matrix small environment the normal adjusting control of proliferous to its, become divided.

Research still discovers to there is negative of chromosome of 5% ~ 10%Ph in CML patient. Patient of Ph chromosome negative although cellular genetics did not discover T(9;22) , but molecular level research, ph chromosome is electronegative (Ph-CML) can be divided again recombine to have Bcr (Ph-bcr CML) and recombine without Bcr (Ph-bcr- CML) two inferior model. Most Ph? CML patient is Ph-bcr CML, ph-bcr-CML patient is minority only. A few authors think latter is likely is slow bead odd leukaemia (CMML) . The branch of research of molecular biology technology to Ph-CML have important sense, have fair value to the patient’s diagnosis, cure and estimation prognosis. Think now Ph? Bcr CML and Ph CML have show of same clinical, hematology, produce acute to change with same way, to α – interferon (the remedial effect of IFN-a) is better;Forum of Shanghai night net

Shanghai night net
And Ph-bcr-CML patient its are clinical behave with hematology all not typical, poorer also to the curative effect of IFN-a. Normally cent is CML 3 period, namely chronic period, quickly period and evil change period, latter is main cause of death. The remedial method with effective only is medullary transplanting (BMT) , especially chronic period curative effect is apparent excel is terminal. Accordingly, choose the most appropriate BMT time to be the key that the patient survives for a long time. But, still forecast its without reliable method up to now evil the time that change. In recent years foreign somebody reported other people of a kind of new molecular gene mark, namely the 11st chromosome short arm (11P) falls calcic element (CT) gene is unusually methylic change a change to be able to monitor CML aggravation. Research hair is chronic now period, it is more normal and methylic change, but can transform into exhibition period in the disease Cheng Chaojia base change. This kind exceeds methylic the Hpa Ⅱ segment that change (3.1Kb) is in clew CML will happen on average inside 6 months evil change (morphology is reached in clinical expression evil before changing) . Accordingly, CT gene height is methylic change can indicate as gene of element of evolutional of the clinical disease that monitor. Pass methylic to CT gene the successive analysis that changes position, can choose patient and buy time to provide a basis for clinical BMT.

Warmth of net of the way to keep in good health hints: Above is to pathogeny of leukaemia of cell of childhood chronic bead, leukaemia of cell of childhood chronic bead is by what reason the relevant content that cause is narrated, more concerns the knowledge of respect of leukaemia of cell of childhood chronic bead, continue to pay close attention to library of disease of net of the way to keep in good health please, perhaps search inside the station ” leukaemia of cell of childhood chronic bead ” find more and patulous content, hope above content can help you!

Introduction of net of the way to keep in good health: The article introduces the pathology pathogeny of wool cell leukaemia in detail to you, wool cell leukaemia basically is caused by what reason.

One, pathogeny of wool cell leukaemia

One, hair cause of disease because:

The pathogeny of 1.HCL not bright, ceng Di gives Ⅱ of virus of leukaemia of person T cell (HTLV- Ⅱ ) , EB virus infection and HCL are concerned. The healthy crowd of correspondence of photograph of ace of incidence of a disease of the person that contact ray or organic dissolvent. Afore-mentioned pathogenies all have a controversy quite, did not obtain approbate. Because have familial in many report that produces HCL, at the same time partial HCL patient has distortion of sex of 12 chromosome clone, 14q respectively, 5, the chromosome such as Del(5q13) is unusual, reason thinks genetic element may come on with HCL about, but did not win consensus likewise.

2, send ill mechanism:

1.HC is put in recomposition of gene of clone sex IgH, but never check gives TCR gene recomposition, reason already was B lymphocyte origin certainly. HC conveys antigen of become divided of B cell surface, if CD19, CD20, CD22 reachs SIg, and do not convey CD10 of mark of inchoate B cell, clew HC is the one B cell that mature level spends in planting. The author puts forward cell of B of area of lymph node brim is the genetic cell of HC, the babyish B lymphocyte in be equivalent to normal circulation reachs lymphocyte of B of odd nucleus appearance. Discover HC still conveys PCA-1 of mark of inchoate oar cell at the same time, indicate level of cell of the oar before its are in. HC surface but check gives a variety of Ig to weigh catenary, support cell of brim area B to may be the normal and corresponding cell of malign HC more.

What 2. cancer gene knows in the action in coming on is very little. The M-CSF that already discovered C-fms codes suffers body to show tall expression in HC, the stimulation that can pass M-CSF thereby promotes the hyperplasia of HC. Additional discovery the Pp60 of child of C-src of former cancer gene of HCL, namely the level of acerbity kinase of ammonia of a kind of cheese and active heighten, cause the proliferation of HC.

Warmth of net of the way to keep in good health hints: Above is fine to wool afterbirth leukaemia pathogeny, wool cell leukaemia is the relevant content that causes by what reason is narrated, more concerns the knowledge of respect of wool cell leukaemia, continue to pay close attention to library of disease of net of the way to keep in good health please, perhaps search inside the station ” wool cell leukaemia ” find more and patulous content, hope above content can help you!

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